ATI RN
ATI Proctored Pharmacology Test
1. When administering digoxin (Lanoxin) to a patient, the healthcare provider observes various signs and symptoms of an overdose. Which of the following should the healthcare provider give to reverse digoxin toxicity?
- A. Naloxone
- B. Vitamin K
- C. Digibind
- D. Flumazenil
Correct answer: C
Rationale: Digibind, also known as Digoxin immune Fab, is the specific antidote used to treat digoxin toxicity. It works by binding to digoxin in the body, forming a complex that can be excreted by the kidneys, thereby reversing the toxic effects of digoxin overdose. Naloxone is used for opioid overdoses, not digoxin toxicity. Vitamin K is used to reverse the effects of warfarin overdose. Flumazenil is used to reverse the effects of benzodiazepine overdose, not digoxin toxicity.
2. A client is starting Simvastatin. Which of the following information should be included in the teaching?
- A. Take this medication in the evening.
- B. Change positions slowly when rising from a chair.
- C. Maintain a steady intake of green leafy vegetables.
- D. Consume no more than 1 L/day of fluid.
Correct answer: A
Rationale: The correct answer is to take simvastatin in the evening. This timing is recommended because nighttime is when the most cholesterol is synthesized in the body. By taking statin medications in the evening, it can enhance their effectiveness in reducing cholesterol levels.
3. Which of the following drugs has a therapeutic effect that increases cardiac output and slows heart rate?
- A. Heparin
- B. Alprazolam
- C. Digoxin
- D. Levothyroxine
Correct answer: C
Rationale: Digoxin is the correct answer. It is a medication known for its positive inotropic effects, which increase cardiac output, and negative chronotropic effects, which slow the heart rate. These effects are achieved by inhibiting the sodium-potassium ATPase pump in myocardial cells. Therefore, Digoxin is commonly prescribed to manage conditions like heart failure and atrial fibrillation, where enhancing cardiac output and reducing heart rate are beneficial. Choices A, B, and D are incorrect because Heparin is an anticoagulant, Alprazolam is a benzodiazepine used for anxiety disorders, and Levothyroxine is a thyroid hormone replacement drug, none of which have the specified therapeutic effects on cardiac function.
4. What is a severe adverse effect of warfarin?
- A. Bleeding
- B. Arrhythmias
- C. Blurred vision
- D. Bradycardia
Correct answer: A
Rationale: A severe adverse effect of warfarin is bleeding. Warfarin is an anticoagulant medication that works by inhibiting blood clotting factors, which can lead to an increased risk of bleeding. Excessive bleeding can occur internally or externally, and it is crucial for individuals taking warfarin to be aware of this potential complication and seek medical attention if they experience any signs of bleeding. Arrhythmias, blurred vision, and bradycardia are not typically associated with warfarin use, making them incorrect choices.
5. A healthcare professional is caring for an older adult client who has a new prescription for Digoxin and takes multiple other medications. Which of the following medications, when used concurrently with Digoxin, places the client at risk for Digoxin toxicity?
- A. Phenytoin
- B. Verapamil
- C. Warfarin
- D. Aluminum hydroxide
Correct answer: B
Rationale: Verapamil, a calcium-channel blocker, can increase digoxin levels, leading to Digoxin toxicity. When these medications are used together, the client is at an increased risk. Phenytoin (Choice A) does not significantly impact digoxin levels. Warfarin (Choice C) and aluminum hydroxide (Choice D) do not directly increase the risk of Digoxin toxicity. Therefore, the correct choice is Verapamil (Choice B) due to its potential to raise digoxin levels and cause toxicity.
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