ATI RN
ATI Pathophysiology
1. A patient has been diagnosed with cytomegalovirus (CMV). Which of the following drugs would be ineffective in the treatment of this disease?
- A. Ribavirin (Rebetol)
- B. Ganciclovir (Cytovene) IV
- C. Foscarnet (Foscavir) IV
- D. Valganciclovir hydrochloride (Valcyte)
Correct answer: A
Rationale: The correct answer is A, Ribavirin (Rebetol). Ribavirin is not effective against CMV. Choice B, Ganciclovir (Cytovene) IV, is a common treatment for CMV as it inhibits viral DNA synthesis. Choice C, Foscarnet (Foscavir) IV, is also used for CMV infections by blocking viral DNA polymerase. Choice D, Valganciclovir hydrochloride (Valcyte), is a prodrug of Ganciclovir and is effective against CMV. Therefore, Ribavirin is the drug that would be ineffective in treating CMV.
2. A patient suffers from dysmenorrhea. Which oral medication will be prescribed that has the ability to provide physiological actions on the neuroendocrine control of ovarian function?
- A. Estrogen
- B. Progestins
- C. Naproxen
- D. Ibuprofen
Correct answer: B
Rationale: Progestins are prescribed for dysmenorrhea as they help reduce menstrual pain by inhibiting ovulation and decreasing the production of prostaglandins. Estrogen (Choice A) is not typically used alone in dysmenorrhea treatment as it can worsen symptoms. Naproxen (Choice C) and Ibuprofen (Choice D) are nonsteroidal anti-inflammatory drugs (NSAIDs) commonly used to relieve pain associated with dysmenorrhea, but they do not directly affect the neuroendocrine control of ovarian function like progestins do.
3. Which of the following describes the etiology of a cerebrovascular accident (CVA)?
- A. A blow to the head from a hard object
- B. Lack of blood flow to part of the brain
- C. Excessive exercise, such as running
- D. A ruptured artery in the heart
Correct answer: B
Rationale: The correct answer is B. A cerebrovascular accident (CVA), or stroke, is often caused by a lack of blood flow to part of the brain. This leads to damage in the brain tissue due to the deprived oxygen and nutrients. Choices A, C, and D are incorrect. A blow to the head from a hard object can cause a traumatic brain injury but is not the etiology of a CVA. Excessive exercise like running does not typically lead to a stroke. A ruptured artery in the heart may result in a heart attack, not a cerebrovascular accident.
4. A 65-year-old man is admitted to the intensive care unit from the operating room after a triple coronary artery bypass graft. He is intubated and on a ventilator. Lactic acid levels were normal postoperatively, but now they are rising. The increased level could be an indication of:
- A. excessive sedation
- B. bowel ischemia
- C. excessive volume infusion in the operating room
- D. mild hypothermia postoperatively
Correct answer: B
Rationale: In this scenario, the rising lactic acid levels in a 65-year-old man after a coronary artery bypass graft could indicate bowel ischemia. Bowel ischemia can lead to anaerobic metabolism, causing an increase in lactic acid levels. Excessive sedation may cause respiratory depression but would not directly lead to rising lactic acid levels. Excessive volume infusion in the operating room might cause fluid overload but would not typically result in rising lactic acid levels. Mild hypothermia postoperatively could lead to shivering and increased oxygen consumption, but it is less likely to be the primary cause of rising lactic acid levels in this context.
5. A 23-year-old pregnant female visits her primary care provider for her final prenatal checkup. The primary care provider determines that the fetus has developed an infection in utero. Which of the following would be increased in the fetus at birth?
- A. IgG
- B. IgA
- C. IgM
- D. IgD
Correct answer: C
Rationale: The correct answer is IgM. IgM is the first antibody produced in response to an infection and is elevated in a fetus with an in utero infection. IgG is the primary antibody responsible for providing immunity to the fetus and is transferred across the placenta during the third trimester. IgA is mainly found in mucosal areas and colostrum but not significantly elevated in fetal infections. IgD is involved in the development and maturation of B cells but not typically increased in fetal infections.
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