Nursing Elites

1. A client who received a renal transplant three months ago is readmitted to the acute care unit with signs of graft rejection. While taking the client's history, the nurse determines the client has been self-administering St. John's wort, an herbal preparation, on the advice of a friend. What information is most significant about this finding?

• A. Wort can decrease plasma concentration of Cyclospora
• B. Wort can decrease plasma concentration of Tacrolimus
• C. Wort can decrease plasma concentration of Cyclosporine
• D. Wort can decrease plasma concentration of Mycophenolate

Correct answer: C

Rationale: The most significant information about the client self-administering St. John's wort, an herbal preparation, is that it can decrease the plasma concentration of Cyclosporine. St. John's wort is known to reduce the efficacy of Cyclosporine, which is a common immunosuppressant drug used to prevent transplant rejection. Choices A, B, and D are incorrect because St. John's wort does not affect the plasma concentration of Cyclospora, Tacrolimus, or Mycophenolate.

2. The practical nurse administered carbidopa-levodopa to a client diagnosed with Parkinson's disease. Which outcome by the client would indicate a therapeutic response?

• A. Decreased blood pressure
• B. Lessening of tremors
• C. Increased salivation
• D. Increased attention span

Correct answer: B

Rationale: The correct answer is B: Lessening of tremors. Carbidopa-levodopa increases the amount of levodopa to the CNS, providing more dopamine to the brain. Increased dopamine levels help alleviate Parkinson's symptoms such as tremors, involuntary movements, and gait abnormalities. Choices A, C, and D are incorrect as carbidopa-levodopa is not expected to have a direct effect on blood pressure, salivation, or attention span in the context of treating Parkinson's disease.

3. A client with hypertension is prescribed clonidine. The nurse should monitor for which potential side effect?

• A. Bradycardia
• B. Tachycardia
• C. Dizziness
• D. Hyperglycemia

Correct answer: A

Rationale: When a client is prescribed clonidine, the nurse should monitor for bradycardia as a potential side effect. Clonidine can lead to a decrease in heart rate, thus causing bradycardia. Monitoring the client's heart rate is crucial to detect and manage this adverse effect.

4. Phenazopyridine is commonly prescribed for clients with urinary tract infections (UTI). Which statement by the practical nurse describes the purpose for the administration of phenazopyridine?

• A. To alter the pH level of the urine
• B. To reduce the frequency of bladder spasms
• C. To alleviate the painful symptoms caused by the UTI
• D. To prevent bacterial replication and resistance development

Correct answer: C

Rationale: The correct answer is C. Phenazopyridine, a urinary analgesic, is utilized to alleviate the pain associated with urinary tract infections (UTIs) like burning, pain, urgency, and frequent voiding. The administration of phenazopyridine can cause the urine to turn a bright red-orange color. It is recommended to take this medication with food to reduce gastric irritation. Phenazopyridine should only be used for a maximum of 2 days when taken alongside an antibacterial agent, which is typically prescribed for about 2 weeks to treat the underlying infection.

5. A client with severe rheumatoid arthritis is prescribed adalimumab. The nurse should monitor for which potential adverse effect?

• A. Increased risk of infection
• B. Bone marrow suppression
• C. Hair loss
• D. Hyperglycemia

Correct answer: A

Rationale: The correct answer is A: Increased risk of infection. Adalimumab is known to increase the risk of infection due to its immunosuppressive effects. Patients on adalimumab should be closely monitored for signs and symptoms of infection, such as fever, chills, and malaise, and should promptly report any such symptoms to their healthcare provider for further evaluation and management. Monitoring for infection is crucial to prevent serious complications in patients receiving adalimumab therapy.

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