HESI RN
Pharmacology HESI
1. A client is taking phenytoin (Dilantin) for seizure control, and a sample for a serum drug level is drawn. Which of the following indicates a therapeutic serum drug range?
- A. 5 to 10 mcg/mL
- B. 10 to 20 mcg/mL
- C. 20 to 30 mcg/mL
- D. 30 to 40 mcg/mL
Correct answer: B
Rationale: The correct therapeutic serum drug level range for phenytoin (Dilantin) is 10 to 20 mcg/mL. This range is considered optimal for seizure control while minimizing the risk of toxicity. Monitoring drug levels helps ensure that the client is within the therapeutic range for effective treatment.
2. In the hierarchy of biology, cells combine to form which of the following?
- A. Macromolecules
- B. Molecules
- C. Tissues
- D. Organelles
Correct answer: C
Rationale: In the hierarchy of biology, cells combine to form tissues. Tissues are groups of cells that work together to perform specific functions. This is a fundamental level of organization above individual cells but below organs and organ systems. Macromolecules and molecules are smaller components that make up cells, not what cells combine to form. Organelles are structures within cells that perform specific functions and do not result from the combination of cells.
3. A 13-year-old client with type 1 diabetes presents to the clinic with a blood glucose level of 400 mg/dL. The client reports feeling thirsty and having frequent urination. What is the nurse’s priority action?
- A. Administer insulin as prescribed
- B. Encourage the client to drink water
- C. Check the client’s urine for ketones
- D. Reinforce the importance of diet and exercise
Correct answer: A
Rationale: In a client with type 1 diabetes presenting with hyperglycemia (blood glucose level of 400 mg/dL) and symptoms of thirst and frequent urination, the priority action for the nurse is to administer insulin as prescribed. Insulin helps lower the blood glucose level and prevents complications like diabetic ketoacidosis. While encouraging hydration is essential, administering insulin is crucial to address the high blood glucose levels. Checking urine for ketones is important in diabetic management but is secondary to administering insulin in this scenario. Reinforcing diet and exercise importance is vital for diabetes management but not the priority in acute hyperglycemia.
4. A middle-aged female client with diabetes mellitus is being treated for the third episode of acute pyelonephritis in the past year. The client asks, 'What can I do to help prevent these infections?' How should the nurse respond?
- A. Test your urine daily for the presence of ketone bodies and proteins.
- B. Use tampons rather than sanitary napkins during your menstrual period.
- C. Drink more water and empty your bladder more frequently during the day.
- D. Keep your hemoglobin A1c under 9% by controlling your blood sugar levels.
Correct answer: C
Rationale: The correct answer is C. Clients with long-standing diabetes mellitus are at risk for pyelonephritis due to various reasons. Elevated blood glucose levels in diabetes can lead to glucose spilling into the urine, altering the pH and creating a conducive environment for bacterial growth. Neuropathy associated with diabetes can reduce bladder tone and diminish the sensation of bladder fullness, resulting in less frequent voiding and increased risk of stasis and bacterial overgrowth. Increasing fluid intake, particularly water, and voiding regularly can help prevent stasis and microbial overgrowth. Testing urine for ketones and proteins or using tampons instead of sanitary napkins are not effective strategies for preventing pyelonephritis. Keeping the hemoglobin A1c levels below 9% is crucial for managing diabetes, but it alone does not directly prevent pyelonephritis.
5. A client with type 2 diabetes mellitus is prescribed metformin. The nurse should monitor the client for which of the following potential side effects?
- A. Lactic acidosis
- B. Hypokalemia
- C. Hyperglycemia
- D. Weight gain
Correct answer: A
Rationale: The correct answer is A, lactic acidosis. Metformin, a common medication for type 2 diabetes mellitus, can lead to lactic acidosis, particularly in individuals with renal impairment or predisposing factors. Monitoring for signs of lactic acidosis, such as muscle pain, weakness, trouble breathing, dizziness, and slow or uneven heart rate, is crucial to prevent serious complications. Choices B, C, and D are incorrect as metformin does not typically cause hypokalemia, hyperglycemia, or weight gain as its primary side effects.