HESI A2
Biology HESI A2 2024
1. How is mitosis different from meiosis?
- A. Mitosis is the process by which body cells are formed.
- B. Meiosis creates cells with half the chromosomes of the parent cell.
- C. Telophase occurs in both mitosis and meiosis.
- D. Spermatogenesis and oogenesis occur via meiosis.
Correct answer: B
Rationale: Meiosis is the type of cell division that creates cells with half the number of chromosomes compared to the parent cell. This is essential for sexual reproduction as it ensures that when the sex cells (sperm and egg) combine during fertilization, the resulting offspring has the correct number of chromosomes. In contrast, mitosis results in two identical daughter cells with the same number of chromosomes as the parent cell. Choice A is incorrect because mitosis is responsible for the division of body cells, not sex cells. Choice C is incorrect because telophase is a phase that occurs in both mitosis and meiosis. Choice D is incorrect because spermatogenesis and oogenesis involve meiosis, not mitosis.
2. Duchenne muscular dystrophy is a recessive sex-linked trait carried on the X chromosome. In an example of an unaffected father and a female carrier who have two daughters and two sons, which is the predicted outcome?
- A. Both daughters will carry the disease.
- B. Both sons will carry the disease.
- C. One daughter may have the disease.
- D. One son may have the disease.
Correct answer: C
Rationale: Duchenne muscular dystrophy is a recessive sex-linked trait carried on the X chromosome. Since the father is unaffected and does not carry the disease, he must have a normal X chromosome. The mother is a carrier, which means she has one normal X chromosome and one X chromosome with the disease allele. The daughters will inherit one X chromosome from each parent; one would be normal, and the other has a chance of carrying the disease allele. So, there is a 50% chance that one daughter may have the disease, as she could inherit the X chromosome with the disease allele. The sons will inherit the Y chromosome from the father and the X chromosome from the mother, so they will not be affected by the disease. Therefore, the predicted outcome is that one daughter may have the disease, while the sons will not carry the disease. This rules out choices A, B, and D.
3. What are the three main events of the haploid cell cycle?
- A. DNA replication, mitosis, and cytokinesis
- B. DNA replication, meiosis, and cytokinesis
- C. DNA replication, cytokinesis, and degradation
- D. Mitosis, meiosis, and apoptosis
Correct answer: A
Rationale: In the haploid cell cycle, the three main events are DNA replication, where the cell's genetic material is duplicated; mitosis, which is the division of the nucleus to ensure each daughter cell receives a complete set of chromosomes; and cytokinesis, the division of the cell cytoplasm to separate the two daughter cells. Meiosis is not part of the haploid cell cycle as it occurs in diploid cells to produce haploid gametes. Apoptosis is a process of programmed cell death and is not a routine event in the cell cycle. Therefore, the correct answer is A. Choices B, C, and D are incorrect as meiosis and apoptosis are not part of the haploid cell cycle, and degradation is not a typical event in the cell cycle.
4. Which of the following structures is not directly involved in translation?
- A. tRNA
- B. mRNA
- C. ribosome
- D. DNA
Correct answer: D
Rationale: The correct answer is 'D: DNA.' DNA is not directly involved in translation, which is the process of synthesizing proteins from mRNA. tRNA carries amino acids to the ribosome, mRNA provides the template for protein synthesis, and ribosomes are the cellular machinery where translation occurs. DNA's main role is in transcription, where it serves as the template for mRNA synthesis, not in translation.
5. How many chromosomes do sperm and egg produce in meiosis?
- A. 46
- B. 23
- C. 45
- D. 24
Correct answer: B
Rationale: Sperm and egg cells undergo meiosis to form gametes with half the number of chromosomes found in somatic cells. Each sperm and egg cell produces 23 chromosomes through meiosis. Choice A is incorrect because 46 chromosomes represent the diploid number found in somatic cells. Choice C is incorrect as it is an uncommon number for chromosome production in human gametes. Choice D is incorrect as the total number of chromosomes in sperm or egg cells is 23, not 24.
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