HESI A2
Biology HESI A2 2024
1. In an example of a male with hemophilia and a female carrier, what ratio of the offspring is predicted to have the disease?
- A. 0 female : 2 males
- B. 1 female : 0 males
- C. 1 female : 2 males
- D. 2 females : 1 male
Correct answer: C
Rationale: In this scenario, the male offspring will inherit the hemophilia trait from their mother due to the sex-linked inheritance pattern. The female offspring will inherit one X chromosome from their mother, becoming carriers of hemophilia. Therefore, the predicted ratio of offspring with the disease would be 1 female as a carrier and 2 males with hemophilia. Choice A is incorrect because there would be male offspring with the disease. Choice B is incorrect as there would be male offspring with hemophilia. Choice D is incorrect as it does not reflect the inheritance pattern of hemophilia.
2. If both parents have polydactylism, what percentage of their offspring is predicted to manifest the anomaly?
- A. 25%
- B. 50%
- C. 75%
- D. 100%
Correct answer: B
Rationale: When both parents have polydactylism, they each possess at least one dominant allele for polydactylism. Through a Punnett square analysis, it can be determined that 50% of their offspring will inherit the dominant allele from both parents. This results in a 100% chance of manifesting the anomaly (2 out of 4 possibilities). Therefore, 50% of the offspring are predicted to manifest the anomaly. Choices A, C, and D are incorrect as they do not align with the principles of Mendelian genetics and Punnett square analysis.
3. How many chromosomes do sperm and egg produce in meiosis?
- A. 46
- B. 23
- C. 45
- D. 24
Correct answer: B
Rationale: Sperm and egg cells undergo meiosis to form gametes with half the number of chromosomes found in somatic cells. Each sperm and egg cell produces 23 chromosomes through meiosis. Choice A is incorrect because 46 chromosomes represent the diploid number found in somatic cells. Choice C is incorrect as it is an uncommon number for chromosome production in human gametes. Choice D is incorrect as the total number of chromosomes in sperm or egg cells is 23, not 24.
4. What is the typical result of mitosis in humans?
- A. two diploid cells
- B. two haploid cells
- C. four diploid cells
- D. four haploid cells
Correct answer: A
Rationale: The correct answer is A: two diploid cells. Mitosis is a type of cell division that results in two daughter cells, each having the same number of chromosomes as the parent cell. In humans, the typical result of mitosis is the formation of two diploid cells, not haploid or four cells. Choice B, two haploid cells, is incorrect because mitosis produces genetically identical diploid cells. Choices C and D, four diploid cells and four haploid cells, respectively, are incorrect as mitosis results in two daughter cells, not four.
5. Which molecule is primarily responsible for storing energy in cells?
- A. Glucose
- B. ATP
- C. Fatty acids
- D. Starch
Correct answer: B
Rationale: ATP is the correct answer because it is the molecule responsible for storing and providing energy in cells. Glucose is a source of energy but not primarily for storage. Fatty acids are more involved in energy production through oxidation. Starch is a polysaccharide used for energy storage in plants.
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