HESI A2
HESI A2 Biology 2024
1. Huntington’s disease is carried on the dominant allele. In a situation where two heterozygous parents have the disease, what percentage of their offspring are predicted to be disease-free?
- A. 0%
- B. 25%
- C. 50%
- D. 100%
Correct answer: B
Rationale: In this scenario, both parents are heterozygous for Huntington's disease, meaning each carries one dominant allele (representing the disease) and one recessive allele (representing no disease). When they have offspring, there is a 25% chance that each child will inherit two recessive alleles, making them disease-free. The Punnett square for two heterozygous parents (Hh x Hh) yields a 25% probability of offspring being homozygous recessive (hh) and therefore disease-free. Choice A (0%) is incorrect because there is a possibility of disease-free offspring. Choice C (50%) is incorrect as it represents the likelihood of being a carrier. Choice D (100%) is incorrect as all offspring will not be disease-free in this scenario.
2. Enzymes are typically _ _.
- A. Fats
- B. Proteins
- C. Sugars
- D. Neurons
Correct answer: B
Rationale: Enzymes are typically proteins that act as biological catalysts, speeding up chemical reactions in living organisms. While most enzymes are made of proteins, a few exceptions, known as ribozymes, are made of RNA. Proteins are composed of amino acids arranged in specific sequences that give enzymes their unique shape and functionality. Choice A, 'Fats,' is incorrect as enzymes are not typically composed of fats. Choice C, 'Sugars,' is incorrect as enzymes are not typically composed of sugars. Choice D, 'Neurons,' is incorrect as neurons are a type of cell in the nervous system, not typically associated with enzymes.
3. 72 chromosomes undergo meiosis. How many chromosomes will be in each gamete?
- A. 18
- B. 36
- C. 72
- D. 144
Correct answer: A
Rationale: During meiosis, the number of chromosomes is halved in each gamete. Since 72 chromosomes undergo meiosis, each gamete will contain half of that number, which is 36 chromosomes. Therefore, the correct answer is 18 chromosomes in each gamete. Choice B (36 chromosomes) is incorrect because it represents the total number of chromosomes that undergo meiosis, not the number in each gamete. Choice C (72 chromosomes) is incorrect as it represents the initial number of chromosomes, not the number in each gamete after meiosis. Choice D (144 chromosomes) is incorrect as it doubles the initial number of chromosomes, which is not the outcome of meiosis.
4. What is the role of tRNA during protein synthesis?
- A. Carries amino acids to the ribosome
- B. Links nucleotides together
- C. Copies DNA sequences
- D. Replicates genetic material
Correct answer: A
Rationale: During protein synthesis, tRNA plays the crucial role of carrying amino acids to the ribosome. This process ensures that the correct amino acids are brought to the ribosome according to the mRNA sequence. Choice B, linking nucleotides together, refers to the role of RNA polymerase in transcription, not tRNA. Choice C, copying DNA sequences, is the function of DNA polymerase during DNA replication, while choice D, replicating genetic material, is an overarching function of DNA replication, not specific to tRNA's role in protein synthesis.
5. Which of the following is necessary for cell diffusion?
- A. water
- B. membrane
- C. ATP
- D. gradient
Correct answer: D
Rationale: The correct answer is 'gradient.' In cell diffusion, substances move from an area of high concentration to an area of low concentration, driven by the concentration gradient. This process does not require water, membrane, or ATP specifically. Water can aid in the movement of substances, but it is not necessary for diffusion itself. The membrane is involved in regulating diffusion but is not a requirement for the process. ATP is not directly involved in simple diffusion processes; instead, it is more related to active transport mechanisms. Therefore, the concentration gradient is essential for cell diffusion to occur.
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