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HESI A2

HESI A2 Biology Practice Test

1. Epithelial cells are:

Correct answer: A

Rationale: Epithelial cells have a distinct top (apical) and bottom (basal) side, demonstrating polarity. This polarity is essential for their specialized functions, such as secretion, absorption, and barrier formation. Choice B, 'Neutral,' is incorrect as epithelial cells exhibit polarity. Choice C, 'Larger than other cells,' is incorrect as epithelial cells come in various sizes and are not specifically larger than other cell types. Choice D, 'None of the above,' is incorrect as epithelial cells are indeed polarized.

2. A cell that does not contain membrane-bound organelles or a defined nucleus would be classified as:

Correct answer: C

Rationale: A cell that does not contain membrane-bound organelles or a defined nucleus is classified as prokaryotic. Prokaryotic cells lack a true nucleus, and their genetic material is typically found in a region called the nucleoid. Examples of prokaryotic organisms include bacteria and archaea. Eukaryotic cells, on the other hand, contain membrane-bound organelles and a true nucleus, distinguishing them from prokaryotic cells. Embryonic and symbiotic classifications are not directly related to the presence of organelles or a nucleus in cells.

3. Which organelle is responsible for detoxifying harmful substances in the cell?

Correct answer: C

Rationale: The correct answer is C, Peroxisomes. Peroxisomes are responsible for detoxifying harmful substances in the cell by breaking down fatty acids and producing hydrogen peroxide. This process helps protect the cell from damage caused by toxic substances. Choice A, Endoplasmic Reticulum, is involved in protein and lipid synthesis, not detoxification. Choice B, Lysosomes, contain enzymes for digestion and waste removal, not primarily detoxification. Choice D, Golgi Apparatus, is responsible for modifying, sorting, and packaging proteins for secretion, not detoxification.

4. During which phase is the chromosome number reduced from diploid to haploid?

Correct answer: D

Rationale: The correct answer is 'meiosis I.' During meiosis I, the chromosome number is reduced from diploid to haploid through two rounds of division. Choice A ('S phase') is incorrect as the S phase is part of the cell cycle where DNA is replicated. Choice B ('interphase') is also incorrect as interphase is the phase where the cell prepares for division. Choice C ('mitosis') is incorrect as mitosis is a process where a diploid cell divides to produce two identical diploid daughter cells, maintaining the chromosome number.

5. In an example of a male with hemophilia and a female carrier, what ratio of the offspring is predicted to have the disease?

Correct answer: C

Rationale: In this scenario, the male offspring will inherit the hemophilia trait from their mother due to the sex-linked inheritance pattern. The female offspring will inherit one X chromosome from their mother, becoming carriers of hemophilia. Therefore, the predicted ratio of offspring with the disease would be 1 female as a carrier and 2 males with hemophilia. Choice A is incorrect because there would be male offspring with the disease. Choice B is incorrect as there would be male offspring with hemophilia. Choice D is incorrect as it does not reflect the inheritance pattern of hemophilia.

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