HESI A2
HESI A2 Biology Practice Test
1. Where is DNA stored?
- A. The nucleus
- B. Ribosomes
- C. Endoplasmic reticulum
- D. Mitochondria
Correct answer: A
Rationale: DNA is stored in the nucleus of a cell. The nucleus houses the cell's genetic material, including the DNA, which contains the instructions for building and operating the cell. The nucleus controls the activities of the cell and is essential for proper cell function and reproduction. Ribosomes are responsible for protein synthesis, not DNA storage. The endoplasmic reticulum is involved in protein and lipid synthesis, storage, and transport but does not store DNA. Mitochondria are known as the powerhouse of the cell, producing energy in the form of ATP, but they do not store DNA.
2. Select the option that best shows complementary base pairing in DNA:
- A. A and G
- B. A and C
- C. A and A
- D. A and T
Correct answer: D
Rationale: The correct answer is D. A purine (A) must pair with a pyrimidine (T) in DNA. This eliminates options A and C as they do not follow the rule of complementary base pairing. Adenine (A) always pairs with thymine (T) due to their specific shape and bonding properties in DNA structure. Choice B is incorrect because adenine does not pair with cytosine in DNA.
3. Epithelial cells are:
- A. Polarized
- B. Neutral
- C. Larger than other cells
- D. None of the above
Correct answer: A
Rationale: Epithelial cells have a distinct top (apical) and bottom (basal) side, demonstrating polarity. This polarity is essential for their specialized functions, such as secretion, absorption, and barrier formation. Choice B, 'Neutral,' is incorrect as epithelial cells exhibit polarity. Choice C, 'Larger than other cells,' is incorrect as epithelial cells come in various sizes and are not specifically larger than other cell types. Choice D, 'None of the above,' is incorrect as epithelial cells are indeed polarized.
4. Which of the following is true of homozygous traits?
- A. They are haploid
- B. They are denoted AA
- C. They are denoted aa
- D. They are denoted Aa
Correct answer: B
Rationale: Homozygous traits have two identical forms of the gene, either both dominant (AA) or both recessive (aa). Therefore, choices B and C are true for homozygous traits. Choice A is incorrect because being haploid refers to having a single set of chromosomes, not necessarily homozygous traits. Choice D is incorrect as homozygous traits have identical alleles, so they are not denoted as Aa.
5. Duchenne muscular dystrophy is a recessive sex-linked trait carried on the X chromosome. In an example of an unaffected father and a female carrier who have two daughters and two sons, which is the predicted outcome?
- A. Both daughters will carry the disease.
- B. Both sons will carry the disease.
- C. One daughter may have the disease.
- D. One son may have the disease.
Correct answer: C
Rationale: Duchenne muscular dystrophy is a recessive sex-linked trait carried on the X chromosome. Since the father is unaffected and does not carry the disease, he must have a normal X chromosome. The mother is a carrier, which means she has one normal X chromosome and one X chromosome with the disease allele. The daughters will inherit one X chromosome from each parent; one would be normal, and the other has a chance of carrying the disease allele. So, there is a 50% chance that one daughter may have the disease, as she could inherit the X chromosome with the disease allele. The sons will inherit the Y chromosome from the father and the X chromosome from the mother, so they will not be affected by the disease. Therefore, the predicted outcome is that one daughter may have the disease, while the sons will not carry the disease. This rules out choices A, B, and D.
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