HESI A2
HESI A2 Biology Practice Test
1. Which of the following shows how information is transformed to make a protein?
- A. DNA-RNA-protein
- B. gene-chromosome-protein
- C. ATP-amino acid-protein
- D. RNA-DNA-protein
Correct answer: A
Rationale: The correct sequence of events for protein synthesis is that DNA is transcribed into RNA, which is then translated into a protein. This process is known as the central dogma of molecular biology. In this sequence, DNA serves as the template for RNA synthesis (transcription), and the RNA serves as the template for protein synthesis (translation). Choice B is incorrect as genes are segments of DNA that code for proteins, and chromosomes are structures that contain DNA. Choice C is incorrect as ATP is an energy molecule and amino acids are the building blocks of proteins, but they are not directly involved in the synthesis process. Choice D is incorrect because RNA is first transcribed from DNA and then used as a template to produce proteins.
2. Which of the following is the best example of a hypothesis?
- A. Dogs like treats
- B. Red is the best color
- C. If I eat 100 donuts, then I will feel sick
- D. If a plant is exposed to red light, then it will show less growth than natural light
Correct answer: D
Rationale: Option D is the best example of a hypothesis because it presents a clear cause-and-effect relationship that can be tested through experimentation. It follows the format of 'If [cause], then [effect]' which is characteristic of a hypothesis in scientific research. The statement is specific, testable, and does not rely on personal opinions or biases, making it a strong and valid hypothesis. Choices A, B, and C do not follow the structure of a hypothesis as they lack the cause-and-effect relationship that can be tested through experimentation. They are more like statements or opinions rather than hypotheses.
3. During which phase of cell division do the chromosomes replicate?
- A. Prophase
- B. Interphase
- C. Anaphase
- D. Telophase
Correct answer: B
Rationale: Chromosomes replicate during the interphase of the cell cycle. Interphase is the phase where the cell prepares for division by undergoing various activities such as growth, DNA replication, and protein synthesis. During DNA replication in interphase, each chromosome in the cell is duplicated to form two sister chromatids, which are then separated during cell division. Prophase is the phase where the chromosomes condense, and the nuclear envelope breaks down. Anaphase is the phase where sister chromatids are pulled apart towards opposite poles of the cell. Telophase is the phase where the nuclear envelope reforms, and chromosomes begin to decondense.
4. Why do high-salt content foods not require refrigeration to prevent spoilage?
- A. Osmosis
- B. Diffusion
- C. Active transport
- D. Passive transport
Correct answer: A
Rationale: Osmosis is the natural process that prevents high-salt content foods from spoiling without the need for refrigeration. Osmosis involves the movement of water across a semi-permeable membrane from an area of lower solute concentration (water) to an area of higher solute concentration (salt). In high-salt content foods, the salt acts as a preservative by drawing moisture out of bacteria or other microorganisms, making it difficult for them to survive and spoil the food. This process helps in preserving the food and preventing spoilage even without refrigeration. Choices B, C, and D are incorrect because they do not involve the specific mechanism of water movement in response to the salt concentration in high-salt content foods.
5. Which of the following is an example of human error in an experiment?
- A. an imperfectly calibrated scale
- B. contaminating a sterile sample by breathing on it
- C. a draft in the laboratory slightly changing the temperature of a liquid
- D. failure to account for wind speed when measuring distance traveled
Correct answer: B
Rationale: Contaminating a sterile sample by breathing on it is an example of human error in an experiment because it involves an action directly caused by the researcher that compromises the integrity of the sample. Breathing on a sterile sample introduces external contaminants that can affect the results. Choices A, C, and D involve factors not directly under the researcher's control or are technical errors that do not involve direct human actions.
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