HESI A2
Biology HESI A2 Practice Test
1. Which of the following is not true about enzymes?
- A. They catalyze reactions
- B. They lower the activation energy needed
- C. They have an active site
- D. They are typically proteins
Correct answer: B
Rationale: Enzymes lower the activation energy needed for a reaction to occur, not raise it. By lowering the activation energy, enzymes facilitate reactions, making them occur more easily and rapidly. Choice A is correct as enzymes indeed catalyze reactions. Choice C is correct as enzymes have specific active sites where substrates bind. Choice D is correct as enzymes are commonly proteins, although some RNA molecules also exhibit catalytic properties.
2. During which phase of cell division do the chromosomes replicate?
- A. Prophase
- B. Interphase
- C. Anaphase
- D. Telophase
Correct answer: B
Rationale: Chromosomes replicate during the interphase of the cell cycle. Interphase is the phase where the cell prepares for division by undergoing various activities such as growth, DNA replication, and protein synthesis. During DNA replication in interphase, each chromosome in the cell is duplicated to form two sister chromatids, which are then separated during cell division. Prophase is the phase where the chromosomes condense, and the nuclear envelope breaks down. Anaphase is the phase where sister chromatids are pulled apart towards opposite poles of the cell. Telophase is the phase where the nuclear envelope reforms, and chromosomes begin to decondense.
3. How many chromosomes do sperm and egg produce in meiosis?
- A. 46
- B. 23
- C. 45
- D. 24
Correct answer: B
Rationale: Sperm and egg cells undergo meiosis to form gametes with half the number of chromosomes found in somatic cells. Each sperm and egg cell produces 23 chromosomes through meiosis. Choice A is incorrect because 46 chromosomes represent the diploid number found in somatic cells. Choice C is incorrect as it is an uncommon number for chromosome production in human gametes. Choice D is incorrect as the total number of chromosomes in sperm or egg cells is 23, not 24.
4. Select the option that best shows complementary base pairing in DNA:
- A. A and G
- B. A and C
- C. A and A
- D. A and T
Correct answer: D
Rationale: The correct answer is D. A purine (A) must pair with a pyrimidine (T) in DNA. This eliminates options A and C as they do not follow the rule of complementary base pairing. Adenine (A) always pairs with thymine (T) due to their specific shape and bonding properties in DNA structure. Choice B is incorrect because adenine does not pair with cytosine in DNA.
5. What cycle is the sequence of reactions by which most living cells generate energy during aerobic respiration?
- A. Calvin Cycle
- B. Krebs Cycle
- C. Photosynthesis
- D. Fermentation
Correct answer: B
Rationale: The Krebs Cycle is the correct answer. It is a series of reactions occurring in the mitochondria and is a crucial part of aerobic respiration. The Calvin Cycle is a part of photosynthesis, not respiration, making choice A incorrect. Photosynthesis (choice C) is the process by which plants, algae, and some bacteria convert light energy into chemical energy. Fermentation (choice D) is an anaerobic process that does not require oxygen and is not the primary energy-generating pathway during aerobic respiration, so it is incorrect.
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