HESI A2
Biology HESI A2 Practice Exam
1. RNA is made from DNA through a process called ___________.
- A. transcription
- B. synthesis
- C. translation
- D. replication
Correct answer: A
Rationale: RNA is made from DNA through a process called transcription. During transcription, an enzyme called RNA polymerase reads the DNA template and synthesizes a complementary RNA molecule. This process is essential for gene expression and allows the information encoded in DNA to be converted into functional RNA molecules. Choice B, 'synthesis,' is incorrect as it is a general term and does not specifically describe the process of RNA formation from DNA. Choice C, 'translation,' is incorrect as it refers to the process where the mRNA is used to assemble amino acids during protein synthesis, not the conversion of DNA to RNA. Choice D, 'replication,' is incorrect as it is the process of making an identical copy of DNA, not converting DNA into RNA.
2. Which of the following shows how information is transformed to make a protein?
- A. DNA-RNA-protein
- B. gene-chromosome-protein
- C. ATP-amino acid-protein
- D. RNA-DNA-protein
Correct answer: A
Rationale: The correct sequence of events for protein synthesis is that DNA is transcribed into RNA, which is then translated into a protein. This process is known as the central dogma of molecular biology. In this sequence, DNA serves as the template for RNA synthesis (transcription), and the RNA serves as the template for protein synthesis (translation). Choice B is incorrect as genes are segments of DNA that code for proteins, and chromosomes are structures that contain DNA. Choice C is incorrect as ATP is an energy molecule and amino acids are the building blocks of proteins, but they are not directly involved in the synthesis process. Choice D is incorrect because RNA is first transcribed from DNA and then used as a template to produce proteins.
3. Which two bases are purines?
- A. Adenine (A)
- B. Cytosine (C)
- C. Thymine (T)
- D. Guanine (G)
Correct answer: A
Rationale: Adenine (A) and guanine (G) are the two bases that are purines. Purines are characterized by a double-ring structure containing two carbon rings, distinguishing them from pyrimidines. Adenine and guanine are purines because they possess this unique double-ring structure. Therefore, choices A and D, adenine and guanine, respectively, are the correct answers. Choices B and C, cytosine and thymine, are pyrimidines and do not exhibit the double-ring structure characteristic of purines.
4. Which is true of the term Phenotype?
- A. It is the genetic code
- B. Phenotype determines genotype
- C. Genotype determines phenotype
- D. Genotype, epigenetic factors, and environmental factors determine phenotype
Correct answer: D
Rationale: The term "phenotype" refers to the observable characteristics or traits of an organism, which are determined by a combination of genotype (genetic makeup), epigenetic factors (modifications to gene expression), and environmental factors (external influences and experiences). Genotype, epigenetic factors, and environmental factors all play a role in determining an individual's phenotype, making option D the correct statement. Options A, B, and C are incorrect because the phenotype is not the genetic code, the phenotype does not determine the genotype, and it is the genotype that influences the phenotype, not the other way around.
5. Which organelle organizes protein synthesis?
- A. mitochondrion
- B. nucleus
- C. ribosome
- D. vacuole
Correct answer: C
Rationale: Ribosomes are the organelles responsible for organizing protein synthesis. They are the protein factories of the cell, where amino acids are linked together to form proteins. Mitochondria are known as the powerhouse of the cell, responsible for energy production. The nucleus contains the cell's genetic material but does not directly organize protein synthesis. Vacuoles are responsible for storage and maintaining the cell's turgidity.
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