HESI A2
Biology HESI A2 2024
1. How should a researcher test the hypothesis that eating chocolate leads to acne in teenagers?
- A. Take 100 teenagers and feed each one a different amount of chocolate daily for 60 days; then test for acne.
- B. Take 100 teenagers and feed 50 two bars of chocolate daily for 60 days while the other 50 eat no chocolate; then test for acne.
- C. Take 1 teenager and feed him or her two bars of chocolate for 30 days and no chocolate for 30 days; then test for acne.
- D. Take 100 teenagers and feed them no chocolate for 30 days and two bars of chocolate apiece for 30 days; then test for acne.
Correct answer: B
Rationale: Option B is the correct approach to test the hypothesis that eating chocolate leads to acne in teenagers. This method involves having a control group (50 teenagers not consuming chocolate) and an experimental group (50 teenagers consuming two bars of chocolate daily), which allows for comparison. By having two distinct groups, researchers can assess the impact of chocolate consumption on acne development. Option A lacks a control group for comparison, making it harder to attribute any observed effects specifically to chocolate consumption. Option C only involves a single subject, which limits the generalizability of the results. Option D, where all teenagers experience both conditions, does not allow for a direct comparison between chocolate consumption and acne development, as all subjects are exposed to both conditions.
2. Imagine that two parents both carry the recessive gene for cystic fibrosis. Any homozygous recessive offspring will manifest the disease. What percentage of the offspring is predicted to be carriers but not manifest the disease?
- A. 0%
- B. 25%
- C. 50%
- D. 100%
Correct answer: B
Rationale: When both parents carry the recessive gene for cystic fibrosis (homozygous recessive), there is a 25% chance for each offspring to inherit two recessive alleles and, therefore, manifest the disease. There is also a 50% chance for each offspring to inherit one recessive allele and one dominant allele, making them carriers of the disease but not manifest it. Therefore, 25% of the offspring are predicted to be carriers but not manifest the disease. Choice A (0%) is incorrect because there is a portion of offspring that will be carriers. Choice C (50%) is incorrect as this percentage corresponds to carriers who will not manifest the disease. Choice D (100%) is incorrect as not all offspring will be carriers and not manifest the disease.
3. The phases of mitosis include:
- A. Prophase, interphase, metaphase, anaphase, and telophase
- B. Prophase, prophase, metaphase, anaphase, and cytokinesis
- C. Prophase, prometaphase, metaphase, anaphase, and telophase
- D. Prophase, interphase, prophase, anaphase, and telophase
Correct answer: C
Rationale: The correct phases of mitosis are prophase, prometaphase, metaphase, anaphase, and telophase. Prophase is the first phase where chromatin condenses into chromosomes, the nuclear envelope breaks down, and the mitotic spindle forms. Prometaphase follows prophase, involving the full disintegration of the nuclear envelope and the attachment of spindle fibers to the kinetochores of the chromosomes. Metaphase is where chromosomes align along the metaphase plate. Anaphase is the phase where sister chromatids separate and move towards opposite poles. Telophase marks the final stage of mitosis, involving the decondensation of chromosomes and the reformation of the nuclear envelope. Choice A is incorrect because it includes interphase, which is not a phase of mitosis. Choice B is incorrect as it repeats prophase, which is the initial phase. Choice D is incorrect because it includes interphase and repeats prophase.
4. Epithelial cells are:
- A. Polarized
- B. Neutral
- C. Larger than other cells
- D. None of the above
Correct answer: A
Rationale: Epithelial cells have a distinct top (apical) and bottom (basal) side, demonstrating polarity. This polarity is essential for their specialized functions, such as secretion, absorption, and barrier formation. Choice B, 'Neutral,' is incorrect as epithelial cells exhibit polarity. Choice C, 'Larger than other cells,' is incorrect as epithelial cells come in various sizes and are not specifically larger than other cell types. Choice D, 'None of the above,' is incorrect as epithelial cells are indeed polarized.
5. What are plasma membranes mostly made of?
- A. Proteins
- B. Carbohydrates
- C. Lipids
- D. Nucleotides
Correct answer: C
Rationale: The correct answer is C: Lipids. Plasma membranes are primarily composed of lipids, specifically phospholipids, which form a lipid bilayer. While proteins are also an essential component of plasma membranes, they are not the primary constituent. Carbohydrates are present on the outer surface of the membrane but are not the main structural component. Nucleotides are the building blocks of nucleic acids like DNA and RNA and are not the main constituents of plasma membranes.
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