HESI A2
Biology HESI A2 Practice Exam
1. Duchenne muscular dystrophy is a recessive sex-linked trait carried on the X chromosome. In an example of an unaffected father and a female carrier who have two daughters and two sons, which is the predicted outcome?
- A. Both daughters will carry the disease.
- B. Both sons will carry the disease.
- C. One daughter may have the disease.
- D. One son may have the disease.
Correct answer: C
Rationale: Duchenne muscular dystrophy is a recessive sex-linked trait carried on the X chromosome. Since the father is unaffected and does not carry the disease, he must have a normal X chromosome. The mother is a carrier, which means she has one normal X chromosome and one X chromosome with the disease allele. The daughters will inherit one X chromosome from each parent; one would be normal, and the other has a chance of carrying the disease allele. So, there is a 50% chance that one daughter may have the disease, as she could inherit the X chromosome with the disease allele. The sons will inherit the Y chromosome from the father and the X chromosome from the mother, so they will not be affected by the disease. Therefore, the predicted outcome is that one daughter may have the disease, while the sons will not carry the disease. This rules out choices A, B, and D.
2. The difference between diploid and haploid is as follows:
- A. Diploid organisms are multicellular
- B. Diploid cells are somatic
- C. Diploid cells have two sets of homologous chromosomes
- D. More than one of the above is true
Correct answer: D
Rationale: Option B correctly states that diploid cells are somatic cells that make up the body tissues and organs in an organism, while haploid cells are gametes involved in sexual reproduction. Option C accurately differentiates diploid and haploid cells based on their chromosome sets – diploid cells have two sets of homologous chromosomes (one from each parent), whereas haploid cells have one set of unpaired chromosomes. Therefore, the correct choice is D, as both statements in options B and C are accurate descriptions of the differences between diploid and haploid cells. Option A is incorrect because diploid and haploid refer to the number of sets of chromosomes in a cell, not whether the organism is multicellular or not.
3. Which names a final step in protein synthesis?
- A. DNA unzips.
- B. Amino acids bond.
- C. Transfer RNA bonds to messenger RNA.
- D. Messenger RNA moves to ribosomes.
Correct answer: B
Rationale: The final step in protein synthesis is when amino acids bond together to form a protein chain. This process occurs during translation, where transfer RNA (tRNA) brings specific amino acids to the ribosome, and the ribosome catalyzes the formation of peptide bonds between the amino acids. This step ultimately leads to the synthesis of a complete protein based on the instructions from messenger RNA (mRNA). Choice A ('DNA unzips') is incorrect as it refers to the initiation of transcription, not the final step of protein synthesis. Choice C ('Transfer RNA bonds to messenger RNA') is incorrect as it describes the process of translation initiation rather than the final step. Choice D ('Messenger RNA moves to ribosomes') is also incorrect as mRNA is already present at the ribosomes throughout the translation process, not just in the final step.
4. What type of cells possess a cell membrane?
- A. Prokaryotic cells only
- B. Eukaryotic cells only
- C. Both prokaryotic and eukaryotic cells
- D. None of the above
Correct answer: C
Rationale: Cell membranes are present in both prokaryotic and eukaryotic cells. The cell membrane serves as a barrier that encloses the cell contents and regulates the entry and exit of substances in and out of the cell. It is a fundamental structure found in all types of cells, regardless of whether they are prokaryotic (lacking a nucleus) or eukaryotic (containing a nucleus). Choice A is incorrect because eukaryotic cells also possess cell membranes. Choice B is incorrect as prokaryotic cells, such as bacteria, also have cell membranes. Choice D is incorrect as both prokaryotic and eukaryotic cells have cell membranes.
5. Why do high-salt content foods not require refrigeration to prevent spoilage?
- A. Osmosis
- B. Diffusion
- C. Active transport
- D. Passive transport
Correct answer: A
Rationale: Osmosis is the natural process that prevents high-salt content foods from spoiling without the need for refrigeration. Osmosis involves the movement of water across a semi-permeable membrane from an area of lower solute concentration (water) to an area of higher solute concentration (salt). In high-salt content foods, the salt acts as a preservative by drawing moisture out of bacteria or other microorganisms, making it difficult for them to survive and spoil the food. This process helps in preserving the food and preventing spoilage even without refrigeration. Choices B, C, and D are incorrect because they do not involve the specific mechanism of water movement in response to the salt concentration in high-salt content foods.
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