HESI A2
HESI A2 Biology Practice Test
1. A child is sick. They have a body temperature that exceeds 37ºC. The body senses this and begins to sweat in order to lower the temperature. What is this an example of?
- A. Positive feedback loop
- B. Negative feedback loop
- C. Both
- D. None of the above
Correct answer: B
Rationale: This is an example of a negative feedback loop. In a negative feedback loop, the body's response (sweating) works to counteract the initial stimulus of a high body temperature by cooling the body down. The goal is to return the body to homeostasis, maintaining a stable internal environment. Positive feedback loops amplify the initial stimulus rather than counteracting it, which is not the case here. Therefore, choices A and C are incorrect. Choice D is also incorrect as the situation described fits the characteristics of a negative feedback loop.
2. Which of the following is true of the Krebs cycle?
- A. It is a redox reaction involving proteins produced during glycolysis
- B. It is a redox reaction involving sugars produced during glycolysis
- C. Protons are passed along a gradient to produce ATP
- D. It is also known as the glycolic acid cycle
Correct answer: B
Rationale: The Krebs cycle, also known as the citric acid cycle, involves a series of redox reactions that occur in the mitochondria. The cycle begins with the oxidation of acetyl CoA, which is derived from the breakdown of sugars produced during glycolysis. These sugars are broken down further in the Krebs cycle to produce ATP and reduce electron carriers such as NADH and FADH2. The cycle does not involve proteins produced during glycolysis. Protons are not passed along a gradient to produce ATP directly in the Krebs cycle; rather, they are used in the electron transport chain to generate ATP. The Krebs cycle is not known as the glycolic acid cycle; glycolysis is the metabolic pathway that produces pyruvate from glucose.
3. Cytosine and thymine are known as:
- A. Purines
- B. Pyrimidines
- C. Both
- D. None of the above
Correct answer: B
Rationale: Cytosine and thymine are known as pyrimidines because they have a single carbon ring structure. Purines, on the other hand, have a double-ring structure. Choice A ('Purines') is incorrect because purines have a double-ring structure, unlike cytosine and thymine. Choice C ('Both') is incorrect as it implies they are both purines and pyrimidines, which is not true. Choice D ('None of the above') is incorrect because cytosine and thymine are indeed pyrimidines.
4. The difference between diploid and haploid is as follows:
- A. Diploid organisms are multicellular
- B. Diploid cells are somatic
- C. Diploid cells have two sets of homologous chromosomes
- D. More than one of the above is true
Correct answer: D
Rationale: Option B correctly states that diploid cells are somatic cells that make up the body tissues and organs in an organism, while haploid cells are gametes involved in sexual reproduction. Option C accurately differentiates diploid and haploid cells based on their chromosome sets – diploid cells have two sets of homologous chromosomes (one from each parent), whereas haploid cells have one set of unpaired chromosomes. Therefore, the correct choice is D, as both statements in options B and C are accurate descriptions of the differences between diploid and haploid cells. Option A is incorrect because diploid and haploid refer to the number of sets of chromosomes in a cell, not whether the organism is multicellular or not.
5. If both parents have polydactylism, what percentage of their offspring is predicted to manifest the anomaly?
- A. 25%
- B. 50%
- C. 75%
- D. 100%
Correct answer: B
Rationale: When both parents have polydactylism, they each possess at least one dominant allele for polydactylism. Through a Punnett square analysis, it can be determined that 50% of their offspring will inherit the dominant allele from both parents. This results in a 100% chance of manifesting the anomaly (2 out of 4 possibilities). Therefore, 50% of the offspring are predicted to manifest the anomaly. Choices A, C, and D are incorrect as they do not align with the principles of Mendelian genetics and Punnett square analysis.
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