Nursing Elites

1. Two mice are both heterozygous for two traits: white fur (Ww) and short fur (Ss). Their offspring are most likely to have which of the following genotypes for these traits?

• A. wwss
• B. WWSS
• C. WwSs
• D. WWSs

Correct answer: C

Rationale: When two mice that are heterozygous for white fur (Ww) and short fur (Ss) mate, they can produce offspring with different combinations of the two traits. The Punnett square for this cross shows that the most likely genotype for the offspring is WwSs. In this case, each offspring receives one allele for white fur (W) and one for short fur (S) from each parent, resulting in a heterozygous genotype for both traits. Choice A (wwss) is incorrect as it represents a homozygous recessive genotype for both traits. Choice B (WWSS) is also incorrect as it represents a homozygous dominant genotype for both traits. Choice D (WWSs) is incorrect as it represents a genotype where one trait is homozygous dominant (W) and the other is heterozygous (S), which is not the most likely outcome based on the given parental genotypes.

2. How many chromosomes must a normal human sperm cell contain?

• A. An X chromosome.
• B. A Y chromosome.
• C. 23 chromosomes.
• D. Both an X and Y chromosome.

Correct answer: C

Rationale: A normal human sperm cell contains a total of 23 chromosomes, half the number found in a typical human cell which has 46 chromosomes. This includes 22 autosomes and one sex chromosome, which can be either an X or a Y chromosome. Therefore, the correct answer is that a normal human sperm cell must contain 23 chromosomes. Choices A and B are incorrect because a single sex chromosome alone does not represent the total number of chromosomes in a sperm cell. Choice D is incorrect because a sperm cell carries only one sex chromosome, either X or Y, not both.

3. What ethical considerations are associated with the potential use of CRISPR-Cas9 technology in humans?

• A. Concerns about unintended consequences on the genome and potential off-target effects.
• B. Debates on modifying the human germline and potential eugenic implications.
• C. Accessibility and affordability of the technology, ensuring equitable access to benefits.
• D. Risks associated with CRISPR-Cas9 editing germline cells and potential long-term impacts.

Correct answer: B

Rationale: The correct answer is B. CRISPR-Cas9 technology allows precise editing of germline cells, raising ethical concerns about modifying the human gene pool. This includes potential eugenic implications, debates on altering future generations, and the moral implications of such genetic modifications. Choice A discusses unintended consequences and off-target effects, but the primary ethical consideration with CRISPR-Cas9 technology relates to altering the human germline. Choices C and D, while important factors, are not the central ethical dilemmas associated with using CRISPR-Cas9 technology in humans.

4. What is the ethical concern surrounding genetic engineering?

• A. Risk of introducing new diseases
• B. Potential for misuse and discrimination
• C. Unforeseen consequences on ecosystems
• D. All of the above

Correct answer: D

Rationale: A) Risk of introducing new diseases: Genetic engineering involves manipulating the genetic material of organisms, which can potentially lead to the creation of new diseases or the spread of existing ones in unintended ways. This risk raises ethical concerns about the potential harm to human health and the environment. B) Potential for misuse and discrimination: Genetic engineering technologies can be misused for purposes such as creating biological weapons or enhancing certain traits in individuals, leading to discrimination based on genetic makeup. This raises ethical concerns about fairness, justice, and the potential for societal harm. C) Unforeseen consequences on ecosystems: Genetic engineering can have unintended consequences on ecosystems, such as disrupting natural balances or harming biodiversity. These unforeseen impacts raise ethical concerns about the responsibility of scientists and policymakers to consider the long-term effects of genetic modifications on the environment. Therefore, the correct answer is D because all the options present valid ethical concerns associated with genetic engineering.

5. Which term is used interchangeably with negative variation?

• A. Non-correlation
• B. Direct correlation
• C. Inverse correlation
• D. Positive correlation

Correct answer: C

Rationale: The correct answer is C: Inverse correlation. Negative variation is synonymous with inverse correlation, indicating that as one variable increases, the other decreases. This relationship is the opposite of positive correlation, where both variables increase or decrease together. Non-correlation and direct correlation do not convey the concept of negative variation and are not interchangeable terms in this context. Non-correlation refers to variables that are not related or associated, while direct correlation indicates that as one variable increases, the other also increases. Positive correlation describes a relationship where both variables increase together, which is the opposite of negative variation.

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