HESI A2
Biology HESI A2 2024
1. In a strand of DNA, you would expect to see adenine paired with ___________.
- A. cytosine
- B. uracil
- C. thymine
- D. guanine
Correct answer: C
Rationale: In a strand of DNA, adenine always pairs with thymine through two hydrogen bonds. This pairing is a fundamental aspect of DNA structure, where adenine and thymine complement each other in the double helix. Choice A (cytosine) is incorrect because adenine does not pair with cytosine in DNA. Choice B (uracil) is incorrect as uracil is found in RNA, not DNA. Choice D (guanine) is incorrect as guanine pairs with cytosine, not adenine, in DNA.
2. Duchenne muscular dystrophy is a recessive sex-linked trait carried on the X chromosome. In an example of an unaffected father and a female carrier who have two daughters and two sons, which is the predicted outcome?
- A. Both daughters will carry the disease.
- B. Both sons will carry the disease.
- C. One daughter may have the disease.
- D. One son may have the disease.
Correct answer: C
Rationale: Duchenne muscular dystrophy is a recessive sex-linked trait carried on the X chromosome. Since the father is unaffected and does not carry the disease, he must have a normal X chromosome. The mother is a carrier, which means she has one normal X chromosome and one X chromosome with the disease allele. The daughters will inherit one X chromosome from each parent; one would be normal, and the other has a chance of carrying the disease allele. So, there is a 50% chance that one daughter may have the disease, as she could inherit the X chromosome with the disease allele. The sons will inherit the Y chromosome from the father and the X chromosome from the mother, so they will not be affected by the disease. Therefore, the predicted outcome is that one daughter may have the disease, while the sons will not carry the disease. This rules out choices A, B, and D.
3. Which statement is untrue?
- A. RNA is single-stranded.
- B. RNA contains uracil.
- C. DNA codes for proteins.
- D. DNA cannot be altered.
Correct answer: D
Rationale: DNA can be altered through various processes such as mutations, genetic engineering, and epigenetic modifications. Changes in DNA can occur naturally or through external influences, leading to variations in the genetic code. Therefore, the statement that DNA cannot be altered is untrue. Choices A, B, and C are true statements. RNA is indeed single-stranded, RNA contains uracil instead of thymine, and DNA serves as a template for protein synthesis.
4. How is the plasma membrane arranged?
- A. In a single layer made of proteins
- B. In a double layer made of proteins
- C. In a single layer of phospholipids
- D. In a double layer of phospholipids
Correct answer: D
Rationale: The plasma membrane is arranged in a double layer of phospholipids, known as a phospholipid bilayer. This structure consists of two layers of phospholipid molecules with hydrophilic heads facing the exterior and hydrophobic tails facing the interior, providing a semipermeable barrier for the cell. Choice A is incorrect because the plasma membrane is not made of a single layer of proteins. Choice B is incorrect as the double layer is composed of phospholipids, not proteins. Choice C is incorrect as the plasma membrane is not made of a single layer of phospholipids but rather a double layer.
5. Which is a byproduct of fermentation in muscle cells?
- A. Ethanol
- B. Pyruvic acid
- C. Lactic acid
- D. Oxygen
Correct answer: C
Rationale: Lactic acid is a byproduct of fermentation in muscle cells. During intense exercise or when oxygen is limited, muscle cells use anaerobic respiration to generate energy. This process breaks down glucose into lactic acid, which can cause muscle fatigue and soreness. Choice A, Ethanol, is not produced in muscle cells during fermentation. Choice B, Pyruvic acid, is an intermediate product in glucose metabolism but is not a byproduct of fermentation in muscle cells. Choice D, Oxygen, is not a byproduct of fermentation but a reactant in aerobic respiration.
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