what is the main idea of the passage about sickle cell anemia

HESI A2

Reading Comprehension Practice Test HESI A2

1. What is the main idea of the passage about Sickle-Cell Anemia?

A. Bone pain is a symptom of sickle-cell anemia.
B. Sickle-cell anemia affects oxygen transport in the body.
C. Sickle-cell anemia is a genetically inherited disease.
D. Sickle-cell anemia is a painful, inherited disease.

Correct answer: D

Rationale: The correct answer is D. The passage focuses on describing sickle-cell anemia as a painful and inherited disease. It details how the abnormal sickle-shaped cells cause symptoms like bone pain, fever, and fatigue. While bone pain is mentioned as a symptom, it is not the main idea of the passage. Choice A is incorrect. Choice B, which mentions oxygen transport, is not the main idea but a general concept. Choice C, stating genetically inherited diseases affect thousands, is too broad and does not focus on the specifics of sickle-cell anemia. Therefore, D is the most precise choice.

2. Which of the following is not listed as a detail in the passage about microbes?

A. Babies are born coated with germs from the birth canal.
B. Mice and humans respond to microbes differently.
C. Few people share the same microbes in the same quantities.
D. Human bodies contain far more microbes than they do cells.

Correct answer: B

Rationale: The correct answer is B because the passage does not detail that mice and humans respond to microbes differently. The passage discusses how laboratory mice required a particular strain of bacteria to help their immune systems function correctly, indicating a difference in how mice and humans respond to microbes. Choices A, C, and D are all details mentioned in the passage: A discusses babies being coated with germs from the birth canal, C talks about the variation in microbes among individuals, and D states that human bodies contain more microbes than cells.

3. Why did the author write the passage on Getting a Good Night's Sleep?

A. To explain insomnia and propose solutions for it.
B. To entertain readers with sleep trivia.
C. To persuade people to sleep more.
D. To inform about the benefits of herbs for sleep.

Correct answer: A

Rationale: The correct answer is A. The author wrote the passage to address the issue of insomnia, offering solutions such as sleep hygiene and non-pharmacological therapies. The passage discusses the challenges of insomnia, its impact on daily life, and emphasizes the importance of seeking help to achieve a good night's sleep. Choice B is incorrect as the passage focuses on a serious topic rather than entertaining with trivia. Choice C is incorrect as the passage does not aim to persuade people to sleep more but to address insomnia specifically. Choice D is incorrect as the passage mentions herbs and spices as part of non-pharmacological therapies for insomnia, not primarily focusing on their benefits.

4. Which of the following statements is an opinion related to Barefoot Running?

A. Running barefoot is natural and advantageous.
B. The cost of modern running shoes keeps increasing.
C. Concrete sidewalks are harder than dirt paths.
D. The arch of the foot gives a spring to the step.

Correct answer: A

Rationale: The statement that "running barefoot is natural and advantageous" reflects a subjective opinion, which cannot be definitively proven or measured objectively. The other statements (B, C, and D) provide factual observations or comparisons that can be validated through evidence, which distinguishes A as the only opinion-based statement.

5. In context, the word 'defective' in the first sentence of the passage means which of the following?

A. Unusual
B. Remarkable
C. Postponed
D. Faulty

Correct answer: D

Rationale: In the context provided, 'defective' means faulty, referring to the gene that causes cystic fibrosis (CF). The passage explains that CF is caused by a defective gene, resulting in the production of abnormally thick and sticky fluid. The word 'defective' suggests that the gene is not functioning correctly, leading to the symptoms associated with the disease. Therefore, 'faulty' is the correct choice. The other options, 'unusual,' 'remarkable,' and 'postponed,' do not accurately capture the meaning of 'defective' in this context and are therefore incorrect.