Nursing Elites

1. What is the 'lock-and-key' model?

• A. Protein folding
• B. Enzyme-substrate interaction
• C. Muscle contraction
• D. Blood clotting

Correct answer: B

Rationale: The 'lock-and-key' model describes the specificity of the interaction between enzymes and their substrates. In this model, the enzyme's active site acts like a lock that can only be opened by the specific substrate molecule, which serves as the key. This specific binding ensures that enzymes catalyze particular reactions and do not interact with other molecules indiscriminately. Protein folding (option A) is the process by which a protein attains its functional three-dimensional structure but is not directly related to the lock-and-key model. Muscle contraction (option C) and blood clotting (option D) are complex biological processes but are not directly associated with the lock-and-key model of enzyme-substrate interaction.

2. What two factors enable some intercellular chemical signals to diffuse across cell membranes and bind to intracellular receptors?

• A. They are small and soluble.
• B. They are large and soluble.
• C. They are small and insoluble.
• D. They are large and insoluble.

Correct answer: A

Rationale: The correct answer is A: 'They are small and soluble.' Small and soluble molecules can easily pass through cell membranes and bind to intracellular receptors. Being small allows them to pass through the membrane, while being soluble enables them to dissolve in the aqueous environment inside the cell. Choice B is incorrect because large molecules typically cannot pass through the cell membrane easily. Choices C and D are incorrect because insoluble molecules would not dissolve in the aqueous environment inside the cell, hindering their ability to bind to intracellular receptors.

3. What is the main function of dietary fiber in the digestive system?

• A. To provide energy
• B. To break down fats
• C. To promote gut bacteria growth
• D. To aid in absorption of nutrients

Correct answer: C

Rationale: Dietary fiber refers to the indigestible portion of plant foods that passes relatively intact through the digestive system. While fiber does not directly provide energy to the body, it plays a crucial role in promoting the growth of beneficial gut bacteria. These bacteria help in the fermentation of fiber, producing short-chain fatty acids that can be used as an energy source by the body. Additionally, fiber aids in regulating bowel movements, maintaining gut health, and supporting overall digestive function. The functions described in the incorrect choices do not align with the primary role of dietary fiber in the digestive system. Choice A is incorrect because fiber itself is not a direct energy source. Choice B is incorrect as fiber does not break down fats. Choice D is incorrect because while fiber affects nutrient absorption indirectly by supporting gut health, its primary role is not to aid in the absorption of nutrients.

4. In which position allows access to the stomach?

• A. Medial
• B. Prone
• C. Superficial
• D. Supine

Correct answer: B

Rationale: The question now specifies the need for a position that allows access to the stomach. The correct answer is 'B: Prone.' In the prone position, the patient lies face down, which facilitates access to the stomach for various procedures or examinations. Choice A, 'Medial,' refers to a direction rather than a patient position. Choice C, 'Superficial,' describes a superficial depth rather than a patient position. Choice D, 'Supine,' is a position where the patient lies face up, which does not provide easy access to the stomach.

5. How do spindle fiber dynamics and microtubule attachment regulate cell cycle checkpoints?

• A. Misaligned chromosomes fail to attach to microtubules, triggering a delay in anaphase onset.
• B. The presence of unattached kinetochores on the centromeres sends a signal to pause cell cycle progression.
• C. Microtubule instability and rapid depolymerization lead to the activation of checkpoint proteins.
• D. All of the above.

Correct answer: D

Rationale: A) Misaligned chromosomes fail to attach to microtubules, triggering a delay in anaphase onset: Proper attachment of chromosomes to spindle fibers is essential for accurate segregation of genetic material during cell division. Misaligned chromosomes that fail to attach to microtubules can lead to delays in anaphase onset, allowing the cell to correct errors before proceeding with division. B) The presence of unattached kinetochores on the centromeres sends a signal to pause cell cycle progression: Kinetochores at the centromeres help attach chromosomes to spindle fibers. When kinetochores are unattached or improperly attached to microtubules, they signal the cell to pause cell cycle progression, ensuring proper chromosome alignment before division. C) Microtubule instability and rapid depolymerization lead to the activation of checkpoint proteins: While microtubule dynamics are crucial for cell division, microtubule instability and rapid depolymerization can disrupt chromosome attachment. However, this mechanism is not directly related to the activation of cell cycle checkpoint proteins, making this statement incorrect. Therefore, choices A and B accurately describe how spindle fiber dynamics and microtubule attachment regulate cell cycle checkpoints, making option D the correct answer.

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