HESI A2
HESI A2 Biology Practice Test
1. The sum of all chemical reactions that occur in an organism is:
- A. product
- B. respiration
- C. metabolism
- D. synthesis
Correct answer: C
Rationale: Metabolism is the sum of all chemical reactions that occur within an organism to maintain life. It involves all the processes that break down molecules to release energy (catabolism) and build new molecules to support growth and maintenance (anabolism). Respiration refers specifically to the process of generating energy from the breakdown of glucose molecules. Synthesis is the creation of complex molecules from simpler ones. Therefore, metabolism is the most comprehensive term that encompasses all these processes within an organism.
2. Which names a final step in protein synthesis?
- A. DNA unzips.
- B. Amino acids bond.
- C. Transfer RNA bonds to messenger RNA.
- D. Messenger RNA moves to ribosomes.
Correct answer: B
Rationale: The final step in protein synthesis is when amino acids bond together to form a protein chain. This process occurs during translation, where transfer RNA (tRNA) brings specific amino acids to the ribosome, and the ribosome catalyzes the formation of peptide bonds between the amino acids. This step ultimately leads to the synthesis of a complete protein based on the instructions from messenger RNA (mRNA). Choice A ('DNA unzips') is incorrect as it refers to the initiation of transcription, not the final step of protein synthesis. Choice C ('Transfer RNA bonds to messenger RNA') is incorrect as it describes the process of translation initiation rather than the final step. Choice D ('Messenger RNA moves to ribosomes') is also incorrect as mRNA is already present at the ribosomes throughout the translation process, not just in the final step.
3. Imagine that two parents both carry the recessive gene for cystic fibrosis. Any homozygous recessive offspring will manifest the disease. What percentage of the offspring is predicted to be carriers but not manifest the disease?
- A. 0%
- B. 25%
- C. 50%
- D. 100%
Correct answer: B
Rationale: When both parents carry the recessive gene for cystic fibrosis (homozygous recessive), there is a 25% chance for each offspring to inherit two recessive alleles and, therefore, manifest the disease. There is also a 50% chance for each offspring to inherit one recessive allele and one dominant allele, making them carriers of the disease but not manifest it. Therefore, 25% of the offspring are predicted to be carriers but not manifest the disease. Choice A (0%) is incorrect because there is a portion of offspring that will be carriers. Choice C (50%) is incorrect as this percentage corresponds to carriers who will not manifest the disease. Choice D (100%) is incorrect as not all offspring will be carriers and not manifest the disease.
4. Physical factors such as temperature and pH can alter enzyme activity because they have an effect on the enzyme's ___________.
- A. acidity
- B. shape
- C. chemistry
- D. substrate
Correct answer: B
Rationale: Physical factors such as temperature and pH can alter enzyme activity by affecting the enzyme's shape. Enzymes rely on their specific shapes to function properly and catalyze reactions. Any changes in temperature or pH can disrupt these shapes, causing the enzyme to become denatured and lose its functionality. Therefore, alterations in temperature and pH can impact enzyme activity by directly affecting their shapes. Choices A, C, and D are incorrect because while pH can affect acidity and chemical properties of the enzyme, and temperature can influence the enzyme-substrate interaction, the primary reason for enzyme activity alteration due to temperature and pH is the change in the enzyme's shape.
5. Which molecules contain only carbon, hydrogen, and oxygen?
- A. Lipids and proteins
- B. Carbohydrates and lipids
- C. Proteins and carbohydrates
- D. Nucleic acids and proteins
Correct answer: B
Rationale: Carbohydrates and lipids are the molecules that contain only carbon, hydrogen, and oxygen. Carbohydrates such as sugars and starches are made up of carbon, hydrogen, and oxygen in a ratio of 1:2:1, while lipids such as fats and oils are composed of carbon, hydrogen, and oxygen as well. Lipids typically contain more carbon and hydrogen atoms compared to oxygen atoms. Proteins contain nitrogen in addition to carbon, hydrogen, and oxygen, while nucleic acids contain phosphorus in addition to carbon, hydrogen, and oxygen. Therefore, choices A, C, and D are incorrect as they include molecules that contain elements other than carbon, hydrogen, and oxygen.
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